Active constituents beta(1-3),(1-6)D-glucans

View detailed beta-D-glucan diagram1

The significant antiviral and immune stimulating properties of Shiitake were not recognised until Japanese scientists isolated several important compounds from Shiitake with well-studied pharmacological effects including LEM and Lentinan2.

The major active constituent of Lentinan is a protein-bound polysaccharide. It contains about 24.6% protein and 44% sugars. The polysaccharide of Shiitake is in a triple helix structure containing glucose molecules with mostly beta-(1-3) linkage and beta-(1-6) side chains3,4.

Traditional use

Records of traditional Chinese use of Shiitake dating back to the Ming Dynasty suggest using Shiitake as a medicinal mushroom to improve stamina and circulation, cure colds and promote good health.

Pharmacological and clinical research

Modern Japanese research has revealed that Lentinan in Shiitake mushroom extract has significant immune modulating, lipid-lowering,
and antiviral properties5.

It has been found to be able to activate macrophages and lymphocytes to modulate the release of cytokines, which may account for its antiviral properties6.

In a clinical trial of 40 patients with chronic hepatitis B, LEM improved liver function and reduced viraemia7.

Always seek medical advice

Information provided on this website is provided for information purposes only and is not intended to replace advice from a qualified medical practitioner. For information about medical conditions please consult your doctor.

Shiitake original research As the leader in standardised mushroom extracts we believe passionately in sharing information from the growing body of published research on medicinal mushrooms. This is for education purposes only and Mycopharma® cannot and does not vouch for the accuracy of independent research. To make your own informed decisions please refer to the original published research about Shiitake.